منابع مشابه
Epileptogenesis, ictogenesis and the design of future antiepileptic drugs.
There is still no medical cure for epilepsy. Clinical epileptology is in need of a "paradigm shift" when it comes to the continuing development of therapeutics. An important first step in this conceptual evolution is differentiating between the notions of ictogenesis and epileptogenesis. All traditional therapeutics are anti-ictogenic, not antiepileptogenic. The future of antiepileptic drug dev...
متن کاملNeuronal mechanism of epileptogenesis in EL mouse
The convulsions of the EL mouse (EL) were described by Imaizumi et al. in 1954 and were established as epilepsy by Suzuki in 1976. The EL mouse has been kept as an inbred strain and is considered one of the best animal models originated in Japan. The mode of inheritance is autosomal dominant, and environmental risk factors for seizure occurrence are hypothesised to contribute to the polygenic b...
متن کاملMolecular mechanism of DNA fragmentation without cell loss in the epileptic mutant EL mice brain
Address correspondence and reprint requests to: Dr. Y. L. Murashima, Department of Neural Plasticity, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan. Tel :+81-3-3304-5701, Fax:+81-3-3329-8035, E-mail: [email protected] In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will be established through experience of...
متن کاملMaternal immune activation promotes hippocampal kindling epileptogenesis in mice.
OBJECTIVE Maternal immune activation (MIA) triggered by infections has been identified as a cause of autism in offspring. Considering the involvement of perturbations in innate immunity in epilepsy, we examined whether MIA represents a risk factor for epilepsy as well. The role of specific MIA components interleukin (IL)-6 and IL-1β was also addressed. METHODS MIA was induced in C57BL/6 mice ...
متن کاملSuppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse overexpressing galanin in neurons under the platelet-derived growth factor B promoter. RIA and HPLC analysis revealed up to 8-fold higher levels of galanin in transgenic as compared with wild-type mi...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2002
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.43.s.5.35.x